Principal Bioinformatician

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Organisation
The Francis Crick Institute
Location
London, United Kingdom
Application Deadline
Reference
13067

Contract: Full time, Fixed-term (2 years)

Salary: Competitive with benefits, subject to skills and experience

Vacancy ID: 13067

Short summary

We are seeking a collaborative and self-motivated bioinformatician to spearhead cancer evolutionary genomics analysis and the design and operation of the bioinformatics next generation sequence pipeline for the TRACERx Renal cancer and associated programmes at the Francis Crick Institute, in the Cancer Dynamics Laboratory. The role is ideally suited for a creative individual with a strong interest in cancer genomics, cancer evolution, software development and testing, database analysis, and automation within a high throughput academic setting interested in working at the Francis Crick Institute. We seek a candidate with strong software engineering and programming skills who is keen to apply these skills to the field of cancer genomics and cancer evolutionary biology. The successful applicant will have previous experience with NGS data analysis, be fluent in at least one of the following programming languages: Python or R, and is expected to have strong skills in the field of genomics and desirably one or more of the following: cancer biology, evolutionary biology, statistics, mathematics or machine learning. Prior experience with data analysis based on integrating large datasets is particularly desired.

Dr Samra Turajlic is the Chief Investigator of the TRACERx Renal initiative (http://tracerx.co.uk/studies/renal/), a largescale longitudinal genomics study in renal cancer utilizing deep multi-region tumour sequencing. Additional translational studies are HOLST-F (NCT03832062) and PEACE (NCT03004755, renal cancer and melanoma), both providing unique windows into cancer progression. The focus of the overall lab programme is the investigation of cancer evolution and the development of high throughput bioinformatics techniques to decipher cancer mutational processes, tumour microenvironmental signals and tumour evolutionary trajectories through the disease course. The candidate will be expected to work within the existing Turajlic lab informatics team and collaborating informaticians at the Crick, and utilise evolutionary, mathematical and statistical methods to deconvolute cancer evolution based in particular but not exclusively upon next generation sequencing data. In addition, the candidate will be expected to have multidisciplinary skills working with clinical and scientific staff and support them in their learning and development.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • The closing date for applications is 02 April 2020 at 23:45.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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